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Your HAPPY NEW YEAR!! Gift
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DNA is constantly changing through mutation
DNA is a dynamic and adaptable molecule. As such, the nucleotide sequences found within it are subject to change as the result of a phenomenon called mutation. Depending on how a particular mutation modifies an organism's genetic makeup, it can prove harmless, helpful, or even hurtful. Click on the image for more information.
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Epigenetics, the science of change.
Environmental Health Scientist, Bob Weinhold informs us that "The term Epigenetic represents an addition to changes that have already happened in DNA sequencing. Today the term includes "any process that alters gene activity without changing the DNA sequence". Developmental Biologist, Ute Deichmann explains "the term “epigenetics” was introduced in 1942 by embryologist Conrad Waddington who related it to the 17th century concept of “epigenesis” and defining it as a complex developmental processes between the genotype and the phenotype." For more information click on the links provided in the names of the scientists above. Today, according to the ABC, Epigenetics is a scientific research revolution that may transform the treatment of cancer.
Epigenetics: Can We Control our Health? by Lucy M Stitzer.
Can diet help to reduce the onset of cancer and/or the need for chemotherapy arising from a diagnosis of cancer? I decided to find out and spent most of last year investigating foods that may help to re-align messages going to and from cellular mitochondria. The following article questions whether or not your DNA is your destiny and offers an insight into the foods that may influence the dreaded messengers of malignant tumors. Click on the following image for more information.
Mitochondria and Cancer by Wei-Xing Zong, Joshua D. Rabinowitz and Eileen White.
ABSTRACT
"Decades ago Otto Warburg observed that cancers ferment glucose in the presence of oxygen, suggesting that defects in mitochondrial respiration may be the underlying cause of cancer. We now know that the genetic events, which drive aberrant cancer cell proliferation, also alter biochemical metabolism including promoting aerobic glycolysis, but do not typically impair mitochondrial function. Mitochondria supply energy, provide building blocks for new cells, and control redox homeostasis, oncogenic signaling, innate immunity and apoptosis. Indeed, mitochondrial biogenesis and quality control are often upregulated in cancers. While some cancers have mutations in nuclear-encoded mitochondrial tricarboxylic acid (TCA) cycle enzymes that produce oncogenic metabolites, there is negative selection for pathogenic mitochondrial genome mutations. Eliminating mitochondrial DNA limits tumorigenesis and rare human tumors with mutant mitochondrial genomes are relatively benign. Thus, mitochondria play a central and multi-functional role in malignant tumor progression, and targeting mitochondria provides therapeutic opportunities." Click on the following image for more information.
"Decades ago Otto Warburg observed that cancers ferment glucose in the presence of oxygen, suggesting that defects in mitochondrial respiration may be the underlying cause of cancer. We now know that the genetic events, which drive aberrant cancer cell proliferation, also alter biochemical metabolism including promoting aerobic glycolysis, but do not typically impair mitochondrial function. Mitochondria supply energy, provide building blocks for new cells, and control redox homeostasis, oncogenic signaling, innate immunity and apoptosis. Indeed, mitochondrial biogenesis and quality control are often upregulated in cancers. While some cancers have mutations in nuclear-encoded mitochondrial tricarboxylic acid (TCA) cycle enzymes that produce oncogenic metabolites, there is negative selection for pathogenic mitochondrial genome mutations. Eliminating mitochondrial DNA limits tumorigenesis and rare human tumors with mutant mitochondrial genomes are relatively benign. Thus, mitochondria play a central and multi-functional role in malignant tumor progression, and targeting mitochondria provides therapeutic opportunities." Click on the following image for more information.
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Wishing you a Happy and Healthy 2021.
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